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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)

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One of those patients is 53-year-old Jenn Rossum, who said she turned to the program with her doctor's approval because she was frustrated that she couldn't lose 20 extra pounds despite skiing, biking and working out most days of the week